Islamabad (UrduPoint / Pakistan Point News / Online – 17th September, 2019) Alternative splicing is a complex but insufficiently understood process. It is crucial to the production of proteins necessary to cell health.
Researchers now believe that cancer cells also use this process to their own advantage.Proteins are large molecules that are absolutely crucial to the health of every single cell in the human body.
However, the processes that determine which, and how many, proteins are available to a cell are complex.In fact, researchers are still studying how some of these processes work.One such process is alternative splicing, which gives cells access to a diverse range of proteins that originate from the same genetic source code but also serves different purposes within the cell, thereby ensuring its health.However, when alternative splicing malfunctions, it can contribute tocancer’s growth, spread, and ability to develop resistance to chemotherapy.Many researchers believe that by regulating alternative splicing, they could find a way to improve cancer therapies.
Yet they still do not fully understand how this complex process works.Now, researchers from the Institute of Cancer Research in London, United Kingdom, have made fresh discoveries about the structure and function of DHX8.
This is a molecule that plays an important role in alternative splicing, and its activity could help explain how cancer can hijack this vital process and use it for its own benefit.
‘Exciting new avenues for cancer treatment’DHX8 plays a role in the final step of splicing, in which genetic information is decoded, and it leads to the production of the diverse forms of protein.In their research, the scientists explore how human DHX8 performs this feat.
They also describe its structure and what function this structure serves.Until now, scientists had a limited understanding of certain regions of DHX8’s structure, including the “DEAH motif,” the “hook loop,” and the “hook turn.” Now, however, the team has succeeded in uncovering more information about how they work.”Our study has shed new light on the structure and function of a crucial protein involved in the process of alternative splicing, in which genetic information is mixed and matched to create multiple protein molecules from a single gene,” says lead study author Rob van Montfort, Ph.D.The researchers’ findings, he believes, could lead to the development of more effective anticancer therapies in the future.